Family: Emperor Emperor Isaac Angelos, II / Irena Comnenus (fam04091)
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 | Andronikos Angelos (1122-1185)
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 | Euryphrosyne Kastamonites (1125-1195)
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| Alexius Angelos, III (1143-1211)  |
| Alexios Angelos Comnenus, III (1155- ) |
| Emperor Emperor Andronikos Comnenos, I (1123-1185)
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| Theodora Kalusine Comnene (1146-1185)
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| Irini Comnene (1168- ) |
| Alexios Comnenos (1170- ) |
| Emperor Emperor Isaac Angelos, II (1156-1204)
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| Irena Comnenus ( -1174)
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